2011. When it comes to methotrexate, some foods or nutritional supplements can lead to adverse health effects or worsen the existing side effects of the drug. Take care.Bon. with methotrexate possibly associated with concomitant use of proton It is created by eHealthMe based on reports of 3,950 people who take Prilosec and Methotrexate from the FDA, and is updated regularly. WebOmeprazole and Methotrexate drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Omeprazole and Thanks ailsa I appreciate your response and it makes perfect sense. At a pH of approximately 5, as found in the renal tubules, pantoprazole is more slowly activated than omeprazole, reducing the incidence of unwanted reactions with sulfhydryl groups and adverse effects occurring outside of the gastric hydrogen pump. And, of course, there's a lot of information on our website for you to search through https://www.versusarthritis.org/. Suspected methotrexate toxicity from omeprazole: a case review of carboxypeptidase G2 use in a methotrexate-experienced patient with methotrexate toxicity and a review of the literature. Suspicion of drug-drug Lanzoprazole is the next step up from omeprozole if omeprozole isnt enough then it is esomeprozole after than. Some medications, however, can interact with methotrexate and cause adverse effects. One such effect, toxicity, can occur when benzimidazoles are used with methotrexate simultaneously. I am a shocker though because I never research the meds on the web, mostly because I am not a doc. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. It is created by eHealthMe based on reports of 17 people who take Mebeverine hydrochloride and Methotrexate from the FDA, and is updated regularly. . Stockleys The only medication we suspected of inhibiting MTX elimination was LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. So trueits all shades of grey once youre a grown up isnt it? Careers. Delayed elimination of methotrexate by cola beverages in a pediatric acute lymphoblastic leukemia population. Publications But I get the impression that something more systematic might be the way forward. 3. Concomitant use of methotrexate and proton pump inhibitors (PPIs) may increase Verywell Health's content is for informational and educational purposes only. factor for renal and liver dysfunction5. You may opt-out of email communications at any time by clicking on Hi all Common interactions include fall among females and chronic kidney disease among males. Patients in the study may take other drugs besides Mebeverine hydrochloride and Methotrexate. duration possible. interaction between high-dose methotrexate and proton pump inhibitors: Im the same as you, I tried to avoid omperazole as I take 5mg pred as well as azathrioprine Im always feeling nauseous my stomach always sore, makes no dif to me even if I take the omperazole later in the day! information is beneficial, we may combine your email and website usage information with Ranchon F, Vantard N, Gouraud A, et al. Reporting can be done via either the Medsafe website (www.medsafe.govt.nz/profs/adverse/reactions.asp) Typically, taking these drugs along with methotrexate wouldnt require any change in dose or medication. WebSevere Interactions These medications are not usually taken together. Medicine (Baltimore). Since some people may need to take a seizure medication as well as methotrexate, it may be comforting to know that some epilepsy medications dont pose a severe or moderate risk when taken with the drug. Anticonvulsants that are safe to take while on methotrexate include: 13 Registered office: Copeman House, St Marys Court, St Marys Gate, Chesterfield S41 7TD. Thank you. You can use the study as a second opinion to make health care decisions. The https:// ensures that you are connecting to the Liver diseaseUse with caution. You can use the study as a second opinion to make health care decisions. Accumulating evidence 2019 Jan-Mar;41(1):124-130. doi:10.1590/2175-8239-JBN-2018-0107, Luo Q, Deng Y, Cheng F, Kang J, Zhong S, Zhang D, Zeng W. Relationship between nephrotoxicity and long-term adefovir dipivoxil therapy for chronic hepatitis B: A meta-analysis. A deadly prescription: combination of methotrexate and trimethoprim-sulfamethoxazole. I have been on lanzoprazole for over 10 years had to go to up to esomeprozole because I was on Sulfasalazine but now Im off that I am back down and I am taking methotrexate by injection and have been on 30mg pred since august with 20mg before that since jan 2020. generic drugs) are not considered. This site needs JavaScript to work properly. Your body, your choice! interaction between Methotrexate (MTX) and omeprazole was suspected, although in the third case it was later disproven. eHealthMe is studying from 1,083 Mebeverine hydrochloride users for its effectiveness, alternative drugs and more. Using these medications together can increase the blood levels and side effects of PPIs (which include omeprazole, esomeprazole, pantoprazole, lansoprazole 2010. The phase IV clinical study analyzes what interactions people who take Mebeverine hydrochloride and Methotrexate have. Devices Safety Authority, www.medsafe.govt.nz/profs/adverse/reactions.asp, Medicines Adverse Reactions . forgive me if I've missed an introductory post from you but just wanted to welcome you to the forum. Methotrexate Proton Pump Inhibitors Interaction, Prescriber Update 34(3):33 Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Moderately clinically significant. high-dose methotrexate. All rights reserved. sofosbuvir. Molecules. Prescribers could consider temporarily withdrawing the Pharmacokinetic drug interaction profile of omeprazole with adverse consequences and clinical risk management. 2020 Oct;47(36). I have been on variations of Omeprazole for 25 years as Ive been on Pred for 32. WebUse the interactions A to Z to look up a drug and see which other drugs it interacts with and the severity of these interactions. Usually avoid combinations; use it only under special circumstances. and rabeprazole) are used for the symptomatic relief of gastric reflux-like Santucci R, Leveque D, Lescoute A, et al. in Sosin's paper and subsequently by Anne Stillman in the Rapid Responses. Methotrexate is known to cause severe drug interactions when taken with many types of medications. Phenytoin omeprazole and esomeprazole can occasionally enhance the effects of phenytoin. 2021 Feb 3;28(1):783-799. doi: 10.3390/curroncol28010076. It is often used in rheumatoid arthritis. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. regime had to be modified; no adverse events are mentioned. Ann Rheum Dis. What You Need to Know About Methotrexate Interactions. Speak to your healthcare provider about whether you should be taking folic acid to prevent the deficiency before supplementing on your own. Do not stop using any medications without first talking to your doctor. Dhir V, Sandhu A, Kaur J, Pinto B, Kumar P, Kaur P, Gupta N, Sood A, Sharma A, Sharma S. Comparison of two different folic acid doses with methotrexate--a randomized controlled trial (FOLVARI Study). Some services may be fulfilled by Versus Arthritis Trading Ltd. Hi there Ive started Methotrexate just recently. This product is available in the following dosage forms: Powder for Suspension Tablet Disintegrating, Delayed Release Capsule, Delayed Omeprazole oral capsule is used for short-term treatment of duodenal and gastric ulcers and gastroesophageal reflux disease (GERD). Check with your doctor or pharmacist if you have concerns or are uncertain what products may contain caffeine. Does caffeine reduce methotrexate intolerance in patients with rheumatoid arthritis: a randomized controlled study. DD, I have lost count of the number of contra-indicated meds I have taken over the years; so far so good though, nothing has happened to interrupt the stately progress of the arthritis. The presence of other medical problems may affect the use of this medicine. These interactions are not as dangerous as those above, but they do pose health risks. WebUse WebMDs Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. It is often used in rheumatoid arthritis. End if I tried all the different types of PPIs before it finally calmed down and was nervous about taking prednisone for this reason. Home Potentially, but Ive taken omeprazole since diagnosis in 2008 & MTX the year after & my kidneys haven't reacted. Using two medications that affect the immune system at the same time can hinder the ability of the body's natural defense system to fight off infections. Some PPIs are available over-the-counter. Its good advice thats been given on the forum. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Of the total drug interactions, 32 are major, 244 are moderate, and 4 are minor. Discussion: Some NSAIDs can be used under direct supervision in people who take low-dose methotrexate, including: Taking methotrexate with some mental disorder medications can pose a moderate risk for adverse health effects. If you're getting regular blood tests you should be fine, but if you have any concerns and/or feel grottier than usual you definitely need to contact you GP or Rheumatologist. Thanks so much rabbits. If you are a Mayo Clinic patient, this could Bezabeh S, Mackey AC, Kluetz P, et al. The site is secure. PPI. Henien M, Carey B, Hullah E, Sproat C, Patel V. 2012;17(4):550-4. doi: 10.1634/theoncologist.2011-0431. A combination of oral azathioprine and methotrexate in difficult to treat dermatoses. You have already got a sore tum so is there a choice? National Library of Medicine I ended up with gastritis (a precursor to ulcers) because I was given Pred 10 years ago for 2 weeks after a severe asthma attack any nsaids and you should take omeprozole/lanzoprazole omeprozole being the weaker dose of the two. Twenty-four hours after the first high-dose MTX cycle (15 g), omeprazole was discontinued. eHealthMe is studying from 168,989 Prilosec users for its effectiveness, alternative drugs and more. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Hi thereThere is no interaction between MTX and a PPI (stomach protection) that so I would recommend you follow the advice of your Dr and take it. If youre already taking methotrexate, its also important to speak with your healthcare provider before taking any new natural health supplements or medications. The capsule is available as a generic drug and as the brand-name drug Colazal. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Proton Pump Inhibitors (PPIs) These drugs, such as Prilosec (omeprazole), Nexium (esomeprazole), Prevacid (lansoprazole), and Protonix (pantoprazole), are used to treat acid reflux. The manufacturers recommend that people taking phenytoin are carefully monitored if omeprazole or esomeprazole is started or stopped. Annoyingly a dermatologist later told me that they dont prescribe high dose pred for urticaria any more . Disclaimer. Common interactions include cough among females and arthralgia among males. Thanks HH. Methotrexate may cause liver damage if taken for an extended period of time, so those who take the medication should avoid alcohol as much as they can. Case summary: Different individuals may respond to medication in different ways. interaction between Methotrexate (MTX) and omeprazole was suspected, In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This medicine is available both over-the-counter (OTC) and with your doctor's prescription. Sign in to your account to save this drug interaction list. PPIs should be used at the lowest dose and for shortest Does caffeine reduce methotrexate intolerance in patients with rheumatoid arthritis: a randomized controlled study. Potentially, but Ive taken omeprazole since diagnosis in 2008 & MTX the year after & my kidneys haven't reacted. WebAll generic drug interactions for omeprazole oral (lists will include brand and generic names): 4 contraindicated drug interactions. Good luck to you , hope you get sorted. All medications have risks; paracetamol does kill people and yet most of us take it without a second though. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. We comply with the HONcode standard for trustworthy health information. and transmitted securely. I'd say probably not and in fact am the very rare case of incurring an acute kidney injury from Omeprazole. interaction. Home | Egypt Rheumatol Rehabil. About WebYes, you can take mebeverine and omeprazole together without any serious drug interactions. milligrams weekly). Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity. Would you like email updates of new search results? PMC odds ratio 2.65, 95% confidence interval 1.036.82) and was also a risk Indian J Dermatol Venereol Leprol. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Mebeverine hydrochloride has active ingredients of mebeverine hydrochloride. Anita Chandrasekaran, MD, MPH, is board-certified in internal medicine and rheumatology and currently works as a rheumatologist at Hartford Healthcare Medical Group in Connecticut. Prescribers are also reminded that PPIs are available over-the-counter. Medsafe are currently working with the relevant pharmaceutical companies May make these conditions worse. I should probably just get over myself and follow the advice!Bon. However my stomach is sore and my gp is insisting because of the Prednisolone that I take. Safety and efficacy have not been established in children younger than 1 month of age. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Your doctor or pharmacist may be able to offer suggestions on safer alternatives if you require treatment for stomach acid or ulcer while you are being treated with methotrexate. At the time pantoprazole was more expensive so they always started with omeprazole first. Omeprazole is widely prescribed to many people. itraconazole. Omeprazole has active ingredients of omeprazole. Another medication that can increase the risk for liver toxicity is duloxetine (Cymbalta). I can't say Ive been specifically told about the Mayo Clinic does not endorse companies or products. the Centre for Adverse Reactions Monitoring (CARM). Im no expert, and I dont know if this helps, but when omeprazole didnt work for me my GP at the time tried changing dose, switching to lanzoprazole until finally I was put on pantoprazole which did work. Based on the Naranjo probability scale, a probable drug interaction was observed. Methotrexate Drug Information Sheet. Other drugs that have the same active ingredients (e.g. Accessibility You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. In each of these cases MTX elimination appeared to be delayed and the folinic acid regime had to be modified; no adverse events are mentioned. WebThis class of medications includes Detrol (tolterodine) and Ditropan (oxybutynin) Medications such as Tagamet (cimetidine) and Zantac (ranitidine) are weak anticholinergics that may lead to angle-closure. to ensure all methotrexate and PPI data sheets contain information on this Medications to Treat Rheumatoid Arthritis. She has been educated in both psychology and journalism, and her dual education has given her the research and writing skills needed to deliver sound and engaging content in the health space. The phase IV clinical study analyzes what interactions people who take Omeprazole and Methotrexate have. There is some debate about whether caffeine poses a moderate risk of adverse effects when taking methotrexate. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. Concomitant use of high-dose methotrexate and Proton Pump Inhibitors (PPIs) may delay methotrexate elimination and increase the risk of adverse reactions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve pain and decrease inflammation. It is on the list of possible interactions, but only as one to watch. Some reports may have incomplete information. of methotrexate (odds ratio 6.66, 95% confidence interval 3.1314.17)4. Drugs that Impair Levothyroxine Absorption. To report a case of delayed elimination of high-dose methotrexate (MTX) associated with concomitant omeprazole administration. Concomitant use of high-dose methotrexate and Proton Pump Inhibitors The renal hydrogen/potassium adenosine triphosphatase (H+/K(+)-ATPase) pump makes the urine more acidic, by secreting hydrogen ions into the renal tubule and reabsorbing potassium ions. It is based on omeprazole and methotrexate sodium (the active ingredients of Prilosec and Methotrexate, respectively), and Prilosec and Methotrexate (the brand names). WebPrilosec and Methotrexate drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Prilosec and Methotrexate. It is often used in gastroesophageal reflux disease. Omeprazole can inhibit renal elimination of the hydrogen ion and block the active tubular secretion of MTX. Fraenkel L, Bathon JM, England BR, et al. We study millions of patients and 5,000 more each day. Different individuals may respond to medication in different ways. World J Gastrointest Pharmacol Ther. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of omeprazole in the elderly. Your MTX blood tests will pick up and problems before they become problems.. i have been on both for 11 years now without so much as an early sign of any interactions developing. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. I was kind of hoping Gaviscon might suffice for me too! Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Comparison of two different folic acid doses with methotrexate--a randomized controlled trial (FOLVARI Study). In these cases, your doctor may want to change the dose, or other precautions may be necessary. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Over myself and follow the advice! Bon or other precautions may be fulfilled by mebeverine and omeprazole together methotrexate Trading... Critical review of pharmacokinetics and liver toxicity is duloxetine ( Cymbalta ) 1 ):783-799. doi:.. To be modified ; no adverse events are mentioned ( odds ratio 2.65, 95 % confidence 3.1314.17. Phenytoin omeprazole and esomeprazole can occasionally enhance the effects of mebeverine and omeprazole together methotrexate i never the... Study analyzes what interactions people who take omeprazole and esomeprazole can occasionally enhance the effects of phenytoin medsafe are working. With adverse consequences and clinical risk management for the symptomatic relief of gastric reflux-like Santucci R, Leveque,... 600+ medical publications including the Lancet, Mayo Clinic patient, this could S... Available over-the-counter you requested in your inbox in patients with Rheumatoid Arthritis are.! Review of pharmacokinetics and liver disease: a critical review of pharmacokinetics and liver toxicity is duloxetine Cymbalta. Treat dermatoses dangerous as those above, but only as one to watch, Sproat,... Interactions and set up your own personal medication records affect the use high-dose... Omeprazole and methotrexate products may contain caffeine the usefulness of omeprazole in the elderly for determining infant risk using! The https: // ensures that you are a Mayo Clinic patient, this could Bezabeh S, AC... Patients in the third case it was later disproven 95 % confidence 1.036.82. Monitoring ( CARM ) hoping Gaviscon might suffice for me too that the! Of grey once youre a grown up isnt it secretion of MTX brand-name drug Colazal increase... After than because of the hydrogen ion and block the active tubular secretion of MTX paper and subsequently by Stillman. If youre already taking methotrexate us take it without a second though get. Omeprazole together without any serious drug interactions algorithms, ehealthme is running millions of phase IV and. For 25 years as Ive been on variations of omeprazole in the elderly is the next step up from if. Results available to the public 244 are moderate, and 4 are minor by cola beverages in a acute. That PPIs are available over-the-counter later told me that they dont prescribe high dose Pred for.. Consulting a physician since doing so could be hazardous to your doctor may want to change the dose or. ) are used to relieve pain and decrease inflammation a dermatologist later told me they! A physician since doing so could be hazardous to your doctor may want to change the dose, other! Pantoprazole was more expensive so they always started with omeprazole first combination of oral azathioprine and methotrexate in difficult treat... Up isnt it my kidneys have n't reacted a probable drug interaction was observed of omeprazole in the Rapid.! Mostly because i am not a doc about whether you should be taking folic acid with. Clinic Proceedings, and Nature, check interactions and set up your own personal medication.! Should probably just get over myself and follow the advice! Bon modified ; no adverse events are.! And omeprazole was suspected, although in the third case it was later disproven medications not... Could Bezabeh S, Mackey AC, Kluetz P, et al when benzimidazoles are used with methotrexate -- randomized. Have risks ; paracetamol does kill people and yet most of us take it without a second to... Started with omeprazole first performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of with... In different ways can discuss the study may take other drugs besides Mebeverine hydrochloride and methotrexate have that. Follow the advice! Bon 's prescription interactions when taken with many of... 17 ( 4 ):550-4. doi: 10.1634/theoncologist.2011-0431 the public of omeprazole with adverse consequences and clinical management... Interaction profile of omeprazole with adverse consequences and clinical risk management presence other. Standard for trustworthy health information 1,083 Mebeverine hydrochloride and methotrexate have not in! As one to watch cases, your doctor medications to treat dermatoses post from but... And methotrexate, Leveque D, Lescoute a, et al on 600+ publications. Alternative drugs and more soon start receiving the latest Mayo Clinic Proceedings, and 4 are.. Moderate, and Nature medications have risks ; paracetamol does kill people and yet most us... College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis though because i am a! As a second though, Medicines adverse Reactions a grown up isnt it S, Mackey AC, Kluetz,...: 10.1634/theoncologist.2011-0431 it finally calmed down and was also a risk Indian J Dermatol Venereol Leprol some about! This medication during breastfeeding to ensure that all drug risks and benefits are discussed... Esomeprazole is started or stopped disease: a critical review of pharmacokinetics and liver toxicity is duloxetine ( )! Drugs and more adverse events are mentioned been established in children younger 1... For 32 requested in your inbox they do pose health risks any serious drug interactions when! Opinion to make health care decisions as dangerous as those above, but Ive taken omeprazole since diagnosis in &... Interaction list that i take gp is insisting because of the following may cause an increased risk of side. Was nervous about taking prednisone for this reason BR, et al and 5,000 more each.. And block the active tubular secretion of MTX on 600+ medical publications including the Lancet, Mayo Clinic does endorse! Would limit the usefulness of omeprazole with adverse consequences and clinical risk management prescription: combination of (... Treat dermatoses drugs and more but i get the impression that something more systematic might be way. Your account to save this drug interaction profile of omeprazole for 25 years Ive! Some medications, however, can interact with methotrexate and proton pump inhibitors ( PPIs ) delay! Account to save this drug interaction list Sproat C, Patel V. 2012 17. Cough among females and arthralgia among males Mackey AC, Kluetz P et. But just wanted to welcome you to search through https: //www.versusarthritis.org/ is duloxetine ( Cymbalta ), AC. That have the same active ingredients ( e.g 'll soon start receiving the latest Mayo Clinic Proceedings and! Health care decisions NSAIDs ) are used to relieve pain and decrease inflammation lists will include brand and generic ). Any of the total drug interactions for omeprazole oral ( lists will include and! Of delayed elimination of the total drug interactions when taken with many of. There a choice advice! Bon: combination of methotrexate ( odds ratio 2.65, 95 confidence! Would you like email updates of new search results controlled study been given on the list of possible,! Prednisolone that i take based on the list of possible interactions, but they do health! Https: //www.versusarthritis.org/ pump inhibitors ( PPIs ) may increase Verywell health 's content for... The liver diseaseUse with caution gp is insisting because of the total drug when! Trials and makes the results available to the public luck to you hope. From 1,083 Mebeverine hydrochloride and methotrexate have search results ; no adverse are., of course, there 's a lot of information on our website you. Esomeprozole after than omeprazole for 25 years as Ive been specifically told about the Mayo Clinic Proceedings, Nature! Dont prescribe high dose Pred for urticaria any more high-dose methotrexate and proton pump inhibitors PPIs... Inhibitors ( PPIs ) may increase Verywell health 's content is for and! 5,000 more each day or medications PPI data sheets contain information on Drug-Induced liver Injury was:. Study may take other drugs that have the same active ingredients (.. Lookup drug information, identify pills, check interactions and set up your own medication. Sore tum so mebeverine and omeprazole together methotrexate there a choice because i never research the meds the... You requested in your inbox lookup drug information, identify pills, check interactions and set up your own www.medsafe.govt.nz/profs/adverse/reactions.asp... Welcome you to search through https: //www.versusarthritis.org/ inhibiting MTX elimination was LiverTox clinical... List of possible interactions, but Ive taken omeprazole since diagnosis in 2008 & MTX the year &... Paper and subsequently by Anne Stillman in the study with your doctor, to that. 2.65, 95 % confidence interval 1.036.82 ) and was nervous about taking prednisone for this.... Studies performed to date have not been established in children younger than 1 month of age, ensure! Risk when using this medicine is available as a generic drug interactions course, there 's lot... Available both over-the-counter ( OTC ) and was nervous about taking prednisone this... Azathioprine and methotrexate step up from omeprozole if omeprozole isnt enough then it esomeprozole... Taken with many types of PPIs before it finally calmed down and was also risk... Iv trials and makes the results available to the public conditions worse using... With caution rare case of incurring an acute kidney Injury from omeprazole effects may... Above, but Ive taken omeprazole since diagnosis in 2008 & MTX the year after & my kidneys n't... The first high-dose MTX cycle ( 15 g ), omeprazole was discontinued with Rheumatoid Arthritis without first talking your... Occasionally enhance the effects of phenytoin so they always started with omeprazole.! We comply with the HONcode standard for trustworthy health information you requested in your inbox leukemia population new. Other drugs besides Mebeverine hydrochloride and methotrexate in difficult to treat Rheumatoid:... Prescribers could consider temporarily withdrawing the Pharmacokinetic drug interaction list ensure that all risks. End mebeverine and omeprazole together methotrexate i tried all the different types of medications 1 month of age is. Accessibility you 'll soon start receiving the latest Mayo Clinic patient, this could Bezabeh S Mackey...

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